8/9/2023 0 Comments Western blot results epmGiven the versatile therapeutic potential of BMSC and BMSC-exos, especially their neuroprotective effect, the aim of this study was to investigate the potential effect of BMSC-exos on AD-like behavioral dysfunction in mice and explore the possible molecular mechanism.īMSC-exos were extracted from the supernatant of cultured mouse BMSCs, which were isolated from the femur and tibia of adult C57BL/6 mice, purified and sorted via flow cytometry, and cultured in vitro. Exosomes derived from bone-marrow mesenchymal stem cells (BMSC-exos) are extracellular vesicles that can execute the function of bone-marrow mesenchymal stem cells (BMSCs). disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive ability. 11 Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, Hefei, China. 10 The Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China. 9 School of Pharmacy, Anhui Medical University, 81 Meishan Road, Anhui, 230032, Hefei, People's Republic of China. 8 Clinical Pharmacy, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China. 7 Psychopharmacology Research Laboratory, Anhui Mental Health Center, Hefei, China.
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